[HTML][HTML] The mysteries of capsaicin-sensitive afferents

MJM Fischer, CI Ciotu, A Szallasi - Frontiers in Physiology, 2020 - frontiersin.org
Capsaicin-induced pain is prevented by the TRPV1 antagonists, capsazepine and BCTC. …
1 μM there is little evidence for non-specific, TRPV1-independent capsaicin actions. At 10 μM …

[HTML][HTML] Membrane interactivity of capsaicin antagonized by capsazepine

M Mizogami, H Tsuchiya - International Journal of Molecular Sciences, 2022 - mdpi.com
… liposomal membranes, capsaicin-induced decreases of DPH … When administered to a rat
tail and spinal cord, capsazepine … reversed the antinociceptive action of capsaicin systemically …

Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative

GM Gonçalves, JM Oliveira… - Clinical and …, 2022 - Wiley Online Library
… in animals injected with capsaicin and capsaicin-induced nociception tests. … with capsazepine
and LS19 (300 µmol/kg). Intraplantar … Some evidence suggests that interference with motor …

[PDF][PDF] Lysionotin exerts antinociceptive effects in various models of nociception induction

A Alqudah, EY Qnais, MA Wedyan, H AlKhateeb… - Heliyon, 2023 - cell.com
Capsaicin-induced paw licking test … mice with naloxone (an opioid antagonist) 15 min before
administering … pain activation by acting on the glutamate receptors or by interacting with NO …

[HTML][HTML] Transient receptor potential channel involvement in antinociceptive effect of citral in orofacial acute and chronic pain models

SAAR Santos, MBMV Damasceno, FEA Magalhães… - EXCLI …, 2022 - ncbi.nlm.nih.gov
… by menthol decreased the capsaicin-induced face rubbing (p < … study with capsazepine (a
competitive TRPV1 antagonist) … ganglion, and trigeminal spinal nucleus in the brainstem and …

TRPV1 blockers as potential new treatments for psychiatric disorders

LP Iglesias, DC Aguiar, FA Moreira - Behavioural Pharmacology, 2022 - journals.lww.com
… TRPV1 is activated by capsaicin (a compound from chili … a new target in psychopharmacology
after evidence of its expression in … by a CB 1 receptor antagonist. Remarkably, under CB 1 …

[PDF][PDF] Analgesic effect of the flavonoid herbacetin in nociception animal models.

M Oqal, E Qnais, A Alqudah… - European Review for …, 2023 - europeanreview.org
antinociceptive action. To investigate the potential mechanisms of action of herbacetin in
modulating pain reception, we performed capsaicin-induced … observed with capsazepine in our …

Suppression of adenosine A2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1

Y Yang, H Zhang, Q Lu, X Liu, Y Fan, J Zhu… - Biochemical …, 2021 - Elsevier
… The TRPV1 antagonist capsazepine blocked bladder … of A 2a receptors reversed
capsaicin-induced nociceptive … Unlike A 2a receptors, A1 receptors have an antinociceptive effect …

[HTML][HTML] Side effects of Opioids are ameliorated by regulating TRPV1 receptors

X Wang, C Bao, Z Li, L Yue, L Hu - International journal of environmental …, 2022 - mdpi.com
… the TRPV1 antagonist SB366791 or capsazepine reduces … Therefore, we summarize the
role of TRPV1 in antinociception … effects of opioids on capsaicin-induced TRPV1 activity [76]. …

[HTML][HTML] Identification of a partial and selective TRPV1 agonist CPIPC for alleviation of inflammatory pain

L Dong, Q Zhou, Q Liang, Z Qiao, Y Liu, L Shao… - Molecules, 2022 - mdpi.com
selective TRPV1 agonist CPIPC that exhibits antinociceptive … agonists (capsaicin and RTX)
and antagonists (capsazepine) … As shown in Figure S3, 1 μM capsaicin induced an inhibition …